The Local Cardiac Renin Angiotensin Aldosterone System

Download or read book Aldosterone-Mineralocorticoid Receptor written by Brian Harvey and published by BoD – Books on Demand. This book was released on 2019-09-25 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.