Computer Aided Drug Design The Hcv Family Example

Download or read book Computer-Aided Drug Design. the Hcv Family Example. written by Dimitrios Vlachakis and published by Lulu.com. This book was released on 2011-06-01 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C and Dengue viruses belong to the family of Flaviviridae. Viruses in this family are enveloped, have positive-sense RNA and are responsible for a variety of life threatening diseases. Hepatitis C virus is the major etiological agent of post-transfusion hepatitis worldwide. An estimated 3 % of the world's population is infected with HCV according to the World Health Organization. Infection with HCV will most regularly result in chronic hepatitis, which leads to liver cirrhosis, hepatocellular carcinoma and liver failure. Dengue is currently the most important viral disease transmitted by mosquitoes afflicting humans the world context. Clinical symptoms range from mild fevers to a severe haemorrhagic disease. To date neither specific antiviral treatments exist nor are there any vaccines available for both infections. Thus there is an urgent need for new therapies.