Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 453 Combined Chronic Toxicity Carcinogenicity Studies

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies
Language: en
Pages: 20
Authors: OECD
Categories:
Type: BOOK - Published: 2018-06-27 - Publisher: OECD Publishing

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The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-respon
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies
Language: en
Pages: 18
Authors: OECD
Categories:
Type: BOOK - Published: 2018-06-27 - Publisher: OECD Publishing

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The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and
OECD Series on Testing and Assessment Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453 Second edition
Language: en
Pages: 156
Authors: OECD
Categories:
Type: BOOK - Published: 2014-09-03 - Publisher: OECD Publishing

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This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 451: Carcinogenicity Studies
Language: en
Pages: 15
Authors: OECD
Categories:
Type: BOOK - Published: 2018-06-27 - Publisher: OECD Publishing

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The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions d