Analysis And Control Of Cellular Ensembles Exploiting Dimensionality Reduction In Single Cell Data And Models

Download Analysis And Control Of Cellular Ensembles Exploiting Dimensionality Reduction In Single Cell Data And Models full books in PDF, epub, and Kindle. Read online free Analysis And Control Of Cellular Ensembles Exploiting Dimensionality Reduction In Single Cell Data And Models ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Analysis and Control of Cellular Ensembles. Exploiting dimensionality reduction in single-cell data and models

Analysis and Control of Cellular Ensembles. Exploiting dimensionality reduction in single-cell data and models
Author :
Publisher : Logos Verlag Berlin GmbH
Total Pages : 145
Release :
ISBN-10 : 9783832552091
ISBN-13 : 383255209X
Rating : 4/5 (09X Downloads)

Book Synopsis Analysis and Control of Cellular Ensembles. Exploiting dimensionality reduction in single-cell data and models by : Karsten Kuritz

Download or read book Analysis and Control of Cellular Ensembles. Exploiting dimensionality reduction in single-cell data and models written by Karsten Kuritz and published by Logos Verlag Berlin GmbH. This book was released on 2020-11-20 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ensemble system is a collection of nearly identical dynamical systems which admit a certain degree of heterogeneity, and which are subject to the restriction that they may only be manipulated or observed as a whole. This thesis presents analysis and control methods for cellular ensembles by considering reduced 1-dimensional dynamics of biological processes in high-dimensional single-cell data and models. To be more specific, we address the quest for real-time analysis of biological processes within single-cell data by introducing the measure-preserving map of pseudotime into real-time, in short MAPiT. MAPiT enables the reconstruction of temporal and spatial dynamics from single-cell snapshot experiments. In addition, we propose a PDE-constrained learning algorithm which allows for efficient inference of changes in cell cycle progression from time series single-cell snapshot data. The second part of this thesis, is devoted to controlling a heterogeneous cell population, in the sense, that we aim at achieving a desired distribution of cellular oscillators on their periodic orbit. A systems theoretic approach to the ensemble control problem provides novel necessary and sufficient conditions for the control of phase distributions in terms of the Fourier coefficients of the phase response curve. This thesis establishes a connection between the previously separate areas of single cell analysis and ensemble control. Our holistic view opens new perspectives for theoretic concepts in basic research and therapeutic strategies in precision medicine.


Analysis and Control of Cellular Ensembles. Exploiting dimensionality reduction in single-cell data and models Related Books

Analysis and Control of Cellular Ensembles. Exploiting dimensionality reduction in single-cell data and models
Language: en
Pages: 145
Authors: Karsten Kuritz
Categories: Language Arts & Disciplines
Type: BOOK - Published: 2020-11-20 - Publisher: Logos Verlag Berlin GmbH

DOWNLOAD EBOOK

An ensemble system is a collection of nearly identical dynamical systems which admit a certain degree of heterogeneity, and which are subject to the restriction
Computational Methods for Single-Cell Data Analysis
Language: en
Pages: 271
Authors: Guo-Cheng Yuan
Categories: Science
Type: BOOK - Published: 2019-02-14 - Publisher: Humana Press

DOWNLOAD EBOOK

This detailed book provides state-of-art computational approaches to further explore the exciting opportunities presented by single-cell technologies. Chapters
Introduction to Single Cell Omics
Language: en
Pages: 129
Authors: Xinghua Pan
Categories:
Type: BOOK - Published: 2019-09-19 - Publisher: Frontiers Media SA

DOWNLOAD EBOOK

Single-cell omics is a progressing frontier that stems from the sequencing of the human genome and the development of omics technologies, particularly genomics,
Frontiers in Massive Data Analysis
Language: en
Pages: 191
Authors: National Research Council
Categories: Mathematics
Type: BOOK - Published: 2013-09-03 - Publisher: National Academies Press

DOWNLOAD EBOOK

Data mining of massive data sets is transforming the way we think about crisis response, marketing, entertainment, cybersecurity and national intelligence. Coll
Tumor Immunology and Immunotherapy - Cellular Methods Part B
Language: en
Pages: 586
Authors:
Categories: Science
Type: BOOK - Published: 2020-01-28 - Publisher: Academic Press

DOWNLOAD EBOOK

Tumor Immunology and Immunotherapy - Cellular Methods Part B, Volume 632, the latest release in the Methods in Enzymology series, continues the legacy of this p