Characterization Of Anti Tumor T Cell Specificities To Inform Engineering Of Antigen Targeted Immunotherapies

Download or read book Characterization of Anti-tumor T Cell Specificities to Inform Engineering of Antigen-targeted Immunotherapies written by Elizabeth E. Grace and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past several decades, advances in immunotherapy have revolutionized cancer treatment. Immune checkpoint blockade has resulted in durable responses for some patients, but others have not seen the same benefits. T cells are essential to the success of many immunotherapies, as their receptors can recognize peptide antigens presented by major histocompatibility complexes (MHCs); productive recognition of antigens displayed by tumors results in T cell-mediated killing of the tumor cells. However, it is not always known what antigens are being recognized by cytotoxic T cells. Thus, there are many avenues of research being pursued to broaden and improve responses to cancer therapy, including T cell antigen identification and the development of combination immunotherapies.