Cytochrome P450 2e1 Its Role In Disease And Drug Metabolism

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Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism

Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism
Author :
Publisher : Springer Science & Business Media
Total Pages : 269
Release :
ISBN-10 : 9789400758810
ISBN-13 : 9400758812
Rating : 4/5 (812 Downloads)

Book Synopsis Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism by : Aparajita Dey

Download or read book Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism written by Aparajita Dey and published by Springer Science & Business Media. This book was released on 2013-02-12 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.


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