PEGylated Protein Drugs: Basic Science and Clinical Applications
| Author | : Francesco M. Veronese |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 289 |
| Release | : 2009-12-30 |
| ISBN-10 | : 9783764386795 |
| ISBN-13 | : 3764386797 |
| Rating | : 4/5 (797 Downloads) |
Download or read book PEGylated Protein Drugs: Basic Science and Clinical Applications written by Francesco M. Veronese and published by Springer Science & Business Media. This book was released on 2009-12-30 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
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