Phosphodiesterases As Drug Targets

Download or read book Phosphodiesterases as Drug Targets written by Sharron H. Francis and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.