Xenobiotic Metabolic Enzymes Bioactivation And Antioxidant Defense

Download or read book Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense written by Chang-Hwei Chen and published by Springer Nature. This book was released on 2020-04-03 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 – ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.